HRID1958736

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6328

Methyl iodide

CH3I

结构：CCOc1ccc(S(=O)(=O)N[C@H](CC(=O)OCc2ccccc2)CN(C)C)cc1NC(=O)N1CCOCC1

HCID86641228

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(S(=O)(=O)N[C@H](CC(=O)OCc2ccccc2)C[N+](C)(C)C)cc1NC(=O)N1CCOCC1.[I-]

HCID68743765

未命名化合物

PROCEDURE

实验过程

According to the method described in example S72b, (R)-benzyl 4-(dimethylamino)-3-(4-ethoxy-3-(morpholine-4-carboxamido)phenylsulfonamido)butanoate was reacted with methyl iodide to give the title compound as a white solid in quantitative yield. MS ESI 563.3 [M+H]+, calcd for [C27H38N4O7S+H]+ 563.25

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8481927dd76449868f491633da5bf050
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08410150B2
来源说明: uspto-grants-2013_04

反应 SMILES

[CH3:1][N:2]([CH3:38])[CH2:3][C@H:4]([NH:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH3:28])=[C:22]([NH:29][C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)=[O:31])[CH:21]=1)(=[O:19])=[O:18])[CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].[CH3:39][I:40]>>[I-:40].[CH2:9]([O:8][C:6](=[O:7])[CH2:5][C@@H:4]([NH:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH3:28])=[C:22]([NH:29][C:30]([N:32]2[CH2:33][CH2:34][O:35][CH2:36][CH2:37]2)=[O:31])[CH:21]=1)(=[O:18])=[O:19])[CH2:3][N+:2]([CH3:39])([CH3:1])[CH3:38])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1