HRID1958746

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2775131

1-Ethynyl-4-pentylbenzene

C13H16

HCID59294388

未命名化合物

PRODUCTS

产物

HCID86641233

未命名化合物

收率 91%

PROCEDURE

实验过程

According to the method described in example S76a, (R)-benzyl 3-(5-bromothiophene-2-sulfonamido)-4-(dimethylamino)butanoate was reacted with 1-ethynyl-4-pentylbenzene to give the title compound as a black oil (68 mg, 91%). MS ESI 553.3 [M+H]+, calcd for [C30H36N2O4S2+H]+ 553.21.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-f89de32672f142e4bfcf1c7f1125ee71
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08410150B2
来源说明: uspto-grants-2013_04

反应SMILES

Br[C:2]1[S:6][C:5]([S:7]([NH:10][C@@H:11]([CH2:23][N:24]([CH3:26])[CH3:25])[CH2:12][C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])(=[O:9])=[O:8])=[CH:4][CH:3]=1.[C:27]([C:29]1[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:31][CH:30]=1)#[CH:28]>>[CH3:25][N:24]([CH3:26])[CH2:23][C@H:11]([NH:10][S:7]([C:5]1[S:6][C:2]([C:28]#[C:27][C:29]2[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:31][CH:30]=2)=[CH:3][CH:4]=1)(=[O:9])=[O:8])[CH2:12][C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14]