3-Chloro-4-hydroxy-5-methoxybenzaldehyde → 3-Chloro-4-hydroxy-5-methoxybenzonitrile

HRID 1958767Notes

Reaction equation

HRID 1958767 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:11][CH3:12])[C:9]=1[OH:10])[CH:5]=O.C(C1C=C(C=C(C)C=1O)C#[N:19])C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:11][CH3:12])[C:9]=1[OH:10])[C:5]#[N:19]

Participants

3

Reactant 2

HCID 296223-Chloro-4-hydroxy-5-methoxybenzaldehydeHCID 597599503-Ethyl-4-hydroxy-5-methylbenzonitrile

Product 1

HCID 12207173-Chloro-4-hydroxy-5-methoxybenzonitrile

Procedure

The title compound is prepared from commercially available 3-chloro-4-hydroxy-5-methoxy-benzaldehyde in analogy to literature procedures (see 3-ethyl-4-hydroxy-5-methyl-benzonitrile). LC-MS: tR=0.82 min; 1H NMR (CDCl3): δ3.98 (s, 3H), 6.36 (s, 1H), 7.04 (s, 1H), 7.34 (s, 1H).

Sources & evidence

ORD record
ord-44e98643d0664b959aaaf094da2ea647
Source dataset
uspto-grants-2013_04
Patent number
US08410151B2

Reaction notes

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