4-Hydroxy-2-Methoxybenzaldehyde → 4-Hydroxy-2-methoxybenzonitrile

HRID 1958768Notes

Reaction equation

HRID 1958768 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([O:10][CH3:11])[CH:3]=1.C(C1C=C(C=C(C)C=1O)C#[N:18])C>>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:18])=[C:4]([O:10][CH3:11])[CH:3]=1

Participants

3

Reactant 2

HCID 5195414-Hydroxy-2-MethoxybenzaldehydeHCID 597599503-Ethyl-4-hydroxy-5-methylbenzonitrile

Product 1

HCID 109536814-Hydroxy-2-methoxybenzonitrile

Procedure

The title compound is prepared from commercially available 4-hydroxy-2-methoxy-benzaldehyde in analogy to literature procedures (see 3-ethyl-4-hydroxy-5-methyl-benzonitrile). LC-MS: tR=0.74 min. 1H NMR (D6-DMSO): δ 3.84 (s, 3H), 6.47 (d, J=8.5 Hz, 1H), 6.54 (s, 1H), 7.49 (d, J=8.5 Hz, 1H), 10.60 (s, 1H).

Sources & evidence

ORD record
ord-619069db00df41d19ee8f2935423468c
Source dataset
uspto-grants-2013_04
Patent number
US08410151B2

Reaction notes

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