4-Hydroxy-2-Methoxybenzaldehyde → HCID 178493425, compound

HRID 1958771Notes

Reaction equation

HRID 1958771 reaction equation
[OH:1][C:2]1C=CC(C=O)=C(OC)C=1.C([C:14]1[CH:15]=[C:16]([CH:21]=[C:22](C)[C:23]=1[OH:24])[C:17]([NH:19][OH:20])=[NH:18])C>>[OH:24][C:23]1[CH:22]=[CH:21][C:16]([C:17]([NH:19][OH:20])=[NH:18])=[C:15]([O:1][CH3:2])[CH:14]=1

Participants

3

Reactant 2

HCID 5195414-Hydroxy-2-MethoxybenzaldehydeHCID 178436626HCID 178436626, compound

Product 1

HCID 178493425HCID 178493425, compound

Procedure

The title compound is prepared from commercially available 4-hydroxy-2-methoxybenzaldehyde in analogy to literature procedures (see 3-ethyl-4,N-dihydroxy-5-methyl-benzamidine). LC-MS: tR=0.41 min; [M+1]+=183.06; 1H NMR (D6-DMSO): δ 3.74 (s, 3H), 5.47 (s, 2H), 6.35 (dd, J=8.3, 1.5 Hz, 1H), 6.45 (s, 1H), 7.21 (d, J=8.5 Hz, 1H), 9.42 (s, 2H).

Sources & evidence

ORD record
ord-8848b084b4564a4a8e3f75b38b9890c2
Source dataset
uspto-grants-2013_04
Patent number
US08410151B2

Reaction notes

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