反应详情

To a solution of methyl 5-(chlorosulfonyl)-2-furoate (3.0 g) in DCM (100 mL) was added tert-butylamine (3.6 mL). After stirring at room temperature for 2 days the mixture was filtered through a pad of celite, washing with DCM (2×10 mL). The filtrate was evaporated to dryness in vacuo. The resulting crude residue was purified by column chromatography using EtOAc/isohexane (2:8) as eluent to give the subtitle compound as a foam. Yield: 2.75 g.

1. filtrationwas filtered through a pad of celite
2. washwashing with DCM (2×10 mL)
3. customThe filtrate was evaporated to dryness in vacuo
4. customThe resulting crude residue was purified by column chromatography