5-(azetidin-1-ylcarbonyl)-N-(tert-butyl)furan-2-sulfonamide → 5-(Azetidin-1-ylcarbonyl)furan-2-sulfonamide

HRID 1958973Notes

Reaction equation

HRID 1958973 reaction equation
[N:1]1([C:5]([C:7]2[O:11][C:10]([S:12]([NH:15]C(C)(C)C)(=[O:14])=[O:13])=[CH:9][CH:8]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1>FC(F)(F)C(O)=O>[N:1]1([C:5]([C:7]2[O:11][C:10]([S:12]([NH2:15])(=[O:14])=[O:13])=[CH:9][CH:8]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 399535195-(azetidin-1-ylcarbonyl)-N-(tert-butyl)furan-2-sulfonamide2×

Product 1

HCID 536283655-(Azetidin-1-ylcarbonyl)furan-2-sulfonamide

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 5-(azetidin-1-ylcarbonyl)-N-(tert-butyl)furan-2-sulfonamide (the product of step ii) (3 g) in trifluoroacetic acid (90 mL) was stirred at room temperature. After 18 h the mixture was evaporated to dryness in vacuo. The resulting oil was triturated with Et2O and filtered to give the subtitle compound as a white solid. Yield: 1.75 g.

Workup

  1. customAfter 18 h the mixture was evaporated to dryness in vacuo
  2. customThe resulting oil was triturated with Et2O
  3. filtrationfiltered

Sources & evidence

ORD record
ord-d41bc571ec204712a729cf7427345a1d
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

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