Tert-Butylamine → HCID 86619885, compound

HRID 1959024Notes

Reaction equation

HRID 1959024 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([S:15](Cl)(=[O:17])=[O:16])=[CH:10][CH:11]=2)[CH2:6]1)=[O:4].[CH3:21][C:22]([NH2:25])([CH3:24])[CH3:23]>C(Cl)Cl>[C:22]([NH:25][S:15]([C:9]1[CH:8]=[C:7]2[C:12]([CH2:13][CH2:14][N:5]([C:3](=[O:4])[C:2]([F:20])([F:19])[F:1])[CH2:6]2)=[CH:11][CH:10]=1)(=[O:17])=[O:16])([CH3:24])([CH3:23])[CH3:21]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 113249022-(Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Product 1

HCID 86619885HCID 86619885, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride (3 g) in DCM (50 ml) was added 2-methylpropan-2-amine (1.73 g). The reaction was then allowed to stir at room temperature 18 h. The reaction was partitioned between H2O (100 ml) and DCM (100 ml). The organics were separated and the aqueous layer was re-extracted with DCM (2×200 ml). Organics were combined, dried (MgSO4) and reduced in vacuo to give the subtitle compound as colourless oil. Yield: 3.56 g

Workup

  1. customThe reaction was partitioned between H2O (100 ml) and DCM (100 ml)
  2. customThe organics were separated
  3. extractionthe aqueous layer was re-extracted with DCM (2×200 ml)
  4. dry with materialdried (MgSO4)

Sources & evidence

ORD record
ord-3f237922628c494e81c0575af1d27909
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

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