Tetrabutylammonium Fluoride → HCID 53628387, compound

HRID 1959026Notes

Reaction equation

HRID 1959026 reaction equation
[Si]([O:8][CH2:9][C@@H:10]([CH2:38][O:39][CH:40]([CH3:42])[CH3:41])[O:11][C:12]1[N:17]=[C:16]([S:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:21]=2[F:27])[N:15]=[C:14]([NH:28][S:29]([C:32]2[N:33]=[CH:34][N:35]([CH3:37])[CH:36]=2)(=[O:31])=[O:30])[CH:13]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[F:27][C:21]1[C:22]([F:26])=[CH:23][CH:24]=[CH:25][C:20]=1[CH2:19][S:18][C:16]1[N:15]=[C:14]([NH:28][S:29]([C:32]2[N:33]=[CH:34][N:35]([CH3:37])[CH:36]=2)(=[O:31])=[O:30])[CH:13]=[C:12]([O:11][C@H:10]([CH2:38][O:39][CH:40]([CH3:41])[CH3:42])[CH2:9][OH:8])[N:17]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 53628388HCID 53628388, compound

Product 1

HCID 53628387HCID 53628387, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

The title compound was prepared according to the procedure outlined in example 34 using N-{6-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(isopropoxymethyl)ethoxy]-2-[(2,3-difluorobenzyl)thio]pyrimidin-4-yl}-1-methyl-1H-imidazole-4-sulfonamide (the product from step (v) (90 mg) in THF (5 mL) and 1M solution of tetrabutylammoniumfluoride in THF (0.28 mL) to give the title compound as a white solid. Yield: 30 mg.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-64d6faf97e0047d390efea0fe891f8e1
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

Loading…