HRID1959032

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4148881

Lithium borohydride

BH4Li

结构：CCOC(=O)[C@@H](C)Oc1cc(NS(=O)(=O)c2cn(C)c(C)n2)nc(SCc2cccc(F)c2F)n1

HCID53628392

未命名化合物

PRODUCTS

生成物

HCID21882825

未命名化合物

结构：Cc1nc(S(=O)(=O)Nc2cc(O[C@H](C)CO)nc(SCc3cccc(F)c3F)n2)cn1C

HCID59558844

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The title compound was prepared according to the procedure outlined in example 11 using a mixture of ethyl (2R)-2-[(2-[(2,3-difluorobenzyl)thio]-6-{[(1,2-dimethyl-1H-imidazol-4-yl)sulfonyl]amino}pyrimidin-4-yl)oxy]propanoate (the product from step (i) (0.25 g), lithium borohydride (2M solution in THF, 0.48 mL) and THF (6 mL). Purification was by reverse phase HPLC (symmetry as the stationary phase and TFA/acetonitrile as the mobile phase) then titurated with Toluene, DCM and then Et2O/iso-hexane to give the title compound as a white solid. Yield: 44 mg

WORKUP

后处理

customThe title compound was prepared
customPurification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fe57628e07ac4d37b4819b79ccb92c3a
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08410123B2
来源说明: uspto-grants-2013_04

反应 SMILES

[F:1][C:2]1[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:3]=1[CH2:4][S:5][C:6]1[N:11]=[C:10]([O:12][C@H:13]([CH3:19])[C:14](OCC)=[O:15])[CH:9]=[C:8]([NH:20][S:21]([C:24]2[N:25]=[C:26]([CH3:30])[N:27]([CH3:29])[CH:28]=2)(=[O:23])=[O:22])[N:7]=1.[BH4-].[Li+]>C1COCC1>[CH3:9][CH2:10][O:12][CH2:13][CH3:14].[CH3:33][CH2:34][CH2:2][CH:3]([CH3:31])[CH3:4].[F:1][C:2]1[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:3]=1[CH2:4][S:5][C:6]1[N:7]=[C:8]([NH:20][S:21]([C:24]2[N:25]=[C:26]([CH3:30])[N:27]([CH3:29])[CH:28]=2)(=[O:23])=[O:22])[CH:9]=[C:10]([O:12][C@H:13]([CH3:19])[CH2:14][OH:15])[N:11]=1