Trifluoroacetic acid → HCID 59558817, compound

HRID 1959057Notes

Reaction equation

HRID 1959057 reaction equation
[F:1][C:2]1[C:35]([F:36])=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][S:5][C:6]1[N:11]=[C:10]([NH:12][S:13]([N:16]2[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][C@H:17]2C)(=[O:15])=[O:14])[CH:9]=[C:8]([O:30][CH3:31])[N:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:19][C@@H:20]1[CH2:18][CH2:17][N:16]([S:13]([NH:12][C:10]2[CH:9]=[C:8]([O:30][CH3:31])[N:7]=[C:6]([S:5][CH2:4][C:3]3[CH:32]=[CH:33][CH:34]=[C:35]([F:36])[C:2]=3[F:1])[N:11]=2)(=[O:15])=[O:14])[CH2:21]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53628404HCID 53628404, compound

Product 1

HCID 59558817HCID 59558817, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl (3R)-4-[({2-[(2,3-difluorobenzyl)thio]-6-methoxypyrimidin-4-yl}amino)sulfonyl]-3-methylpiperazine-1-carboxylate (0.75 g) in DCM (10 ml) was added TFA (10 ml) slowly. The reaction then stirred at room temperature for 18 h. The reaction was reduced in vacuo and the residue purified by prep HPLC to give the title compound as a white solid. Yield: 0.27 g

Workup

  1. customThe reaction
  2. customthe residue purified by prep HPLC

Sources & evidence

ORD record
ord-127ad61e47ae4778a720dbca99bb8ca9
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

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