Trifluoroacetic acid → HCID 59558821, compound

HRID 1959062Notes

Reaction equation

HRID 1959062 reaction equation
COC1C=CC(C[N:10]([C:18]2[CH:23]=[C:22]([O:24][CH3:25])[N:21]=[C:20]([S:26][CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:19]=2)[S:11]([N:14]2[CH2:17][CH2:16][CH2:15]2)(=[O:13])=[O:12])=CC=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:25][O:24][C:22]1[N:21]=[C:20]([S:26][CH2:27][CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[N:19]=[C:18]([NH:10][S:11]([N:14]2[CH2:17][CH2:16][CH2:15]2)(=[O:12])=[O:13])[CH:23]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67051248HCID 67051248, compound

Product 1

HCID 59558821HCID 59558821, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of N-[(4-methoxyphenyl)methyl]-N-[6-methoxy-2-[(2-phenylethyl)thio]pyrimidin-4-yl]azetidine-1-sulfonamide (the product of step iii, 0.17 g) in DCM (1 ml) and TFA (2 ml) was stirred at room temperature for 18 h. The solvent was evaporated under reduced pressure. The residue was recrystallised from EtOAc and iso-hexane to give the title product as a white solid. Yield: 50 mg.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallised from EtOAc and iso-hexane

Sources & evidence

ORD record
ord-32e7c9adb00540a585e4b773a79efc9d
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

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