2-Iodobenzoic acid → HCID 826819, compound

HRID 1959097Notes

Reaction equation

HRID 1959097 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[SH:9].[OH-].[K+].I[C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]>CN(C=O)C>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]

Participants

5

Reactant 3

HCID 69412-Iodobenzoic acidHCID 14797Potassium HydroxideHCID 1402022,3-Dichlorobenzenethiol

Product 1

HCID 826819HCID 826819, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

FIG. 2 is a flow chart for manufacturing the compound No. 1. First, 2,3-dichlorobenzenethiol (0.90 g, 5 mmol) is dissolved in 10 ml DMF solution, and 10 ml of 1N KOH(aq) is added thereinto. After stirring the mixture under room temperature for 10˜15 minutes, 2-iodobenzoic acid (1.24 g, 5 mmol) is dissolved in 10 ml of DMF solution. And then, 0.315 g of Cupper powder is added into the mixture, and the mixture is treated by a reverse flow under 120□ for 8 hours. After filtering the mixture, the filtrate is neutralized with 10 ml of 1N HCl(aq), and a precipitate will be produced. After filtering and washing the precipitate by water, 2-(2,3-dichlorophenylthio)benzoic acid is obtained.

Workup

  1. additionAnd then, 0.315 g of Cupper powder is added into the mixture
  2. additionthe mixture is treated by a reverse flow under 120□ for 8 hours
  3. filtrationAfter filtering the mixture
  4. customa precipitate will be produced
  5. filtrationAfter filtering
  6. washwashing the precipitate by water

Sources & evidence

ORD record
ord-74dc7d00cb3745de9d7ff9dd3975eaae
Source dataset
uspto-grants-2013_04
Patent number
US08410161B2

Reaction notes

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