Hydrochloric Acid → HCID 66744467, compound

HRID 1959422Notes

Reaction equation

HRID 1959422 reaction equation
[C:1]([N:5]1[CH2:9][C:8]2([CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH2:7][CH2:6]1)(=[O:4])[CH2:2][CH3:3].Cl>C(Cl)Cl.O1CCOCC1>[CH2:7]1[C:8]2([CH2:13][CH2:12][NH:11][CH2:10]2)[CH2:9][N:5]([C:1](=[O:4])[CH2:2][CH3:3])[CH2:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66745092Tert-butyl 7-propionyl-2,7-diazaspiro[4.4]nonane-2-carboxylate

Product 1

HCID 66744467HCID 66744467, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 3-propanoyl-3,7-diazaspiro[4.4]nonane-7-carboxylate (153 mg, 0.54 mmol) in DCM (0.5 mL) was added a solution of hydrogen chloride (1.4 mL of 4 M, 5.4 mmol) in dioxane. The reaction mixture was stirred at room temperature for 1 h. The solvents were removed under reduced pressure and the crude product was dried on the high vacuum for 1 h to yield 1-(3,7-diazaspiro[4.4]nonan-3-yl)propan-1-one as an off white gum. LC/MS m/z 183.3 [M+H]+.

Workup

  1. customThe solvents were removed under reduced pressure
  2. dry with materialthe crude product was dried on the high vacuum for 1 h

Sources & evidence

ORD record
ord-5e23ce4042914834b5c54c59d1543f0c
Source dataset
uspto-grants-2013_04
Patent number
US08410112B2

Reaction notes

Loading…