反应详情

温度

0 °C

To a stirred solution of 3-amino-N-methoxy-4-methyl-benzamide 1 (104 mg, 0.58 mmol) in water (2 ml) at 0° C. was added conc. HCl (2 mL) followed by the addition of sodium nitrite (44 mg, 0.63 mmol). The reaction mixture was stirred at 0° C. for 40 minutes then a solution of tin(II)chloride (245 mg, 1.30 mmol) in conc. HCl (1 mL) was added and the mixture was stirred for 40 minutes then allowed to stand at −20° C. for 20 hours before it was warmed to RT and concentrated to a white solid. The solid was triturated with ethanol, the solids were removed, and 2-benzoyl-3-phenylamino-acrylonitrile 5 (144 mg, 0.58 mmol, preparation: Grothaus, J. Am. Chem. Soc. 58, 1334 (1936)) was added and the mixture heated (bath T=65-70° C.) for 16 hr. The mixture was cooled to RT, concentrated and purified by flash chromatography, eluting with 1:1 EtOAc/hexanes to remove impurities then 100% EtOAc to give 3-(5-amino-4-benzoyl-pyrazol-1-yl)-N-methoxy-4-methyl-benzamide 6 as an off-white solid (41 mg, 0.12 mmol, 28%). HPLC (4 minute gradient) tR1.93 min; MS m/z 351.1 [M+H]+; 1H NMR (DMSO-d6, 300 MHz) δ 11.88 (s 1H, NH), 7.803 (m, 4H), 7.56 (m, 4H), 7.01 (s, 2H, NH2), 3.32 (s, 3H), 2.162 (s, 3H) ppm; 13C NMR (DMSO-d6, 125 MHz) δ 187.6, 151.9, 141.2, 139.7, 139.6, 135.7, 131.4, 131.2, 130.9, 128.5, 128.1, 127.8, 126.4, 102.6, 63.2, 17.2 ppm.

1. stirringthe mixture was stirred for 40 minutes
2. waitto stand at −20° C. for 20 hours before it
3. temperaturewas warmed to RT
4. concentrationconcentrated to a white solid
5. customThe solid was triturated with ethanol
6. customthe solids were removed
7. temperaturethe mixture heated (bath T=65-70° C.) for 16 hr
8. temperatureThe mixture was cooled to RT
9. concentrationconcentrated
10. custompurified by flash chromatography
11. washeluting with 1:1 EtOAc/hexanes
12. customto remove impurities