反应详情

To a solution of 1-[5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-2-methoxy-ethanone (0.14 g, 0.46 mmol) in ethanol (15 mL) p-TsOH monohydrate was added. After stirring overnight at RT, solvent was evaporated and the residue was purified by flash chromatography on silica gel with EA/hexane to provide the title compound as a colourless oil. MS (m/z): 216.0 [M+H+].

1. customsolvent was evaporated
2. customthe residue was purified by flash chromatography on silica gel with EA/hexane