HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-2-methoxy-ethanone → 1-(5-Chloro-4-hydroxymethyl-pyridin-3-yl)-2-methoxy-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-2-methoxy-ethanone | HCID 67077143 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(5-Chloro-4-hydroxymethyl-pyridin-3-yl)-2-methoxy-ethanone | HCID 67077485 | — |
Reaction Steps
To a solution of 1-[5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-2-methoxy-ethanone (0.14 g, 0.46 mmol) in ethanol (15 mL) p-TsOH monohydrate was added. After stirring overnight at RT, solvent was evaporated and the residue was purified by flash chromatography on silica gel with EA/hexane to provide the title compound as a colourless oil. MS (m/z): 216.0 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410134B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-07d6efae1b904e5baf1e91f19225471a |
| Source note | uspto-grants-2013_04 |