3-Bromo-5-chloropyridine-4-carboxaldehyde → HCID 86645357, compound

HRID 1959569Notes

Reaction equation

HRID 1959569 reaction equation
BrC1[CH:3]=[N:4]C=C(Cl)C=1C=O.S1C=CN=C1S.[Cl:17][C:18]1C=N[CH:21]=[C:22]([S:26][C:27]2[S:28][CH:29]=[CH:30][N:31]=2)[C:23]=1[CH:24]=[O:25]>ClC1C=C(Cl)C=CN=1>[Cl:17][C:18]1[C:23]([CH:24]=[O:25])=[C:22]([S:26][C:27]2[S:28][CH:29]=[CH:30][N:31]=2)[CH:21]=[CH:3][N:4]=1

Participants

5

Reactant 3

HCID 730126133-Bromo-5-chloropyridine-4-carboxaldehydeHCID 86645358HCID 86645358, compoundHCID 178527881HCID 178527881, compound

Product 1

HCID 86645357HCID 86645357, compound

Reagents, catalysts & solvents 1

HCID 335152,4-DichloropyridineSolvent

Procedure

Introduction of the formyl group in 2,4-dichloro-pyridine according to the synthesis of 3-bromo-5-chloro-pyridine-4-carbaldehyde and subsequent reaction with thiazole-2-thiol according to the synthesis of 3-chloro-5-(thiazol-2-ylsulfanyl)-pyridine-4-carbaldehyde yielded the title compound. MS (m/z): 257.2 [H+H+].

Sources & evidence

ORD record
ord-ee1eb291b2d740afb2c69f64092ee720
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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