化工社化工社 化学情報印刷レポート · 研究参考用
Citric Acid → Bromo-acetic acid 2,4-dinitro-phenyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citric Acid | HCID 311 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 2,4-Dinitrophenol | HCID 1493 | — |
| 反応物 | Bromoacetyl bromide | HCID 61147 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Bromo-acetic acid 2,4-dinitro-phenyl ester | HCID 11278141 | — |
反応手順
Under argon atmosphere bromo-acetyl bromide (2.67 mL, 30.66 mmol) dissolved in DCM (15 mL) was added within 15 min to a mixture of 2,4-dinitro-phenol (5.13 g, 27.88 mmol) and pyridine (2.92 mL, 36.24 mmol) in DCM (40 mL) at 0° C. After 1 h at RT, aqueous citric acid solution (10%, 30 mL) was added to the reaction mixture. The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The resulting residue recrystallized from diethyl ether (75 mL) to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08410134B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-73231533228d4ba39352ee3bca1e76e9 |
| 出典メモ | uspto-grants-2013_04 |