Potassium tert-butoxide → HCID 44190365, compound

HRID 1959584Notes

Reaction equation

HRID 1959584 reaction equation
CC([O-:5])(C)C.[K+].[Cl:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12](Cl)[C:13]=1[CH2:14][O:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][O:17]1>O1CCOCC1>[Cl:7][C:8]1[C:13]([CH2:14][O:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][O:17]2)=[C:12]([OH:5])[CH:11]=[N:10][CH:9]=1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 44190364HCID 44190364, compound

Product 1

HCID 44190365HCID 44190365, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

Potassium tert-butylate (1.77 g, 15.80 mmol) was added to a stirred solution of 3,5-dichloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridine (825 mg, 3.16 mmol) in dioxane. After stirring for 3 d at 100° C. the solvent was removed in vacuo. The resulting title compound was used for the next reaction without purification. MS (m/z): 243.8 [M+H+].

Workup

  1. customwas removed in vacuo
  2. customThe resulting title compound was used for the next reaction without purification

Sources & evidence

ORD record
ord-ab3b9aa7343b42c289b5cedf45898f18
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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