Thionyl Chloride → HCID 67078322, compound

HRID 1959585Notes

Reaction equation

HRID 1959585 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:10][CH2:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)[C:7]=1[CH2:8]O.O=S(Cl)[Cl:20].C(N1C=CN=C1SC1C=NC=C(Cl)C=1CCl)CCC>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([O:10][CH2:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)[C:7]=1[CH2:8][Cl:20]

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 67077290HCID 67077290, compoundHCID 67077751HCID 67077751, compound

Product 1

HCID 67078322HCID 67078322, compound

Procedure

[3-Chloro-5-(tetrahydro-pyran-2-ylmethoxy)-pyridin-4-yl]-methanol (10 mg, 0.039 mmol) was chlorinated with SOCl2 according to the synthesis of 3-(1-butyl-1H-imidazol-2-ylsulfanyl)-5-chloro-4-chloromethyl-pyridine. The resulting title compound was used for the next reaction without purification. MS (m/z): 276.0 [M+H+].

Sources & evidence

ORD record
ord-92dea9784ded4450ace6d5e7114a15f7
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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