Thionyl Chloride → HCID 67077180, compound

HRID 1959589Notes

Reaction equation

HRID 1959589 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH:5]([CH3:19])[C:6]([NH:8][CH2:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([Cl:18])[C:15]=1[CH2:16]O)=[O:7].O=S(Cl)[Cl:23].ClC1C=NC=C(Cl)C=1CCl>>[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH:5]([CH3:19])[C:6]([NH:8][CH2:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([Cl:18])[C:15]=1[CH2:16][Cl:23])=[O:7]

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 226268533,5-Dichloro-4-(chloromethyl)pyridineHCID 67078189HCID 67078189, compound

Product 1

HCID 67077180HCID 67077180, compound

Procedure

N-(5-Chloro-4-hydroxymethyl-pyridin-3-ylmethyl)-3-methyl-succinamic acid methyl ester (1.39 mg, 0.0046 mmol) was chlorinated with SOCl2 according to the synthesis of 3,5-dichloro-4-chloromethyl-pyridine. The resulting title compound was used for the next reaction without purification. MS (m/z): 318.9 [M+H+].

Sources & evidence

ORD record
ord-32a3f8a7e04a41019bb593d5943c5918
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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