4-Chloro-8-hydroxy-2-methylquinoline → HCID 67077596, compound

HRID 1959598Notes

Reaction equation

HRID 1959598 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1.[CH3:14][C:15]1[S:19][C:18]([SH:20])=[N:17][N:16]=1>CO>[CH3:13][C:4]1[CH:3]=[C:2]([S:20][C:18]2[S:19][C:15]([CH3:14])=[N:16][N:17]=2)[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=1

Participants

4

Reactant 2

HCID 122197224-Chloro-8-hydroxy-2-methylquinolineHCID 178434161HCID 178434161, compound

Product 1

HCID 67077596HCID 67077596, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 4-chloro-2-methyl-quinolin-8-ol (10 mg, 52 μmol) and 5-methyl-[1,3,4]thiadiazole-2-thiol (6.9 mg, 52 μmol) in MeOH (0.3 mL) was heated to 80° C. for 1.5 h. The solvent was removed in vacuo to give title compound. MS (m/z): 289.9 [M+H+].

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-35cdf1bf3c1b4e08889535c8baa0d4f8
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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