HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-1H-imidazole-5-carbonitrile → 2-(8-Hydroxy-2-methyl-quinolin-4-yl)-3-methyl-3H-imidazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-1H-imidazole-5-carbonitrile | HCID 2795425 | — |
| Reactant | 4-Bromo-2-methyl-quinolin-8-ol | HCID 67077159 | — |
| Reactant | 2-Methyl-4-(1-methyl-1H-imidazol-2-yl)-quinolin-8-ol | HCID 135950306 | — |
| Product | 2-(8-Hydroxy-2-methyl-quinolin-4-yl)-3-methyl-3H-imidazole-4-carbonitrile | HCID 136346375 | — |
Reaction Steps
Coupling of 4-bromo-2-methyl-quinolin-8-ol (400 mg. 1.68 mmol) with 3-methyl-3H-imidazole-4-carbonitrile (450 mg. 4.20 mmol) according to the synthesis of 2-methyl-4-(1-methyl-1H-imidazol-2-yl)-quinolin-8-ol yielded the title compound. MS (m/z): 265.2 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410134B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-bd625cb49dc9408fb5181df0dd466ede |
| Source note | uspto-grants-2013_04 |