Trifluoroacetic acid → 4-(aminomethyl)-N-[4-[[5-(4-phenylphenyl)pyrazolo[1,5-c]pyrimidin-7-yl]amino]phenyl]benzamide;2,2,2-trifluoroacetic acid

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Reaction Steps

A mixture of {4-[4-(5-biphenyl-4-yl-pyrazolo[1,5-c]pyrimidin-7-ylamino)-phenylcarbamoyl]benzyl}-carbamic acid tert-butyl ester (compound A1)(0.14 g) and trifluoroacetic acid (TFA)(1 ml) in dichloromethane (5 ml) is stirred 3 h at ambient temperature. The reaction mixture is evaporated, coevaporated with toluene and dried at high vacuum. Colorless crystals (0.13 g) are obtained in quantitative yield and a transition temperature of 170° C. and a melting temperature at 230° C.

Provenance & Evidence