反应详情

A mixture of {4-[4-(5-biphenyl-4-yl-pyrazolo[1,5-c]pyrimidin-7-ylamino)-phenylcarbamoyl]benzyl}-carbamic acid tert-butyl ester (compound A1)(0.14 g) and trifluoroacetic acid (TFA)(1 ml) in dichloromethane (5 ml) is stirred 3 h at ambient temperature. The reaction mixture is evaporated, coevaporated with toluene and dried at high vacuum. Colorless crystals (0.13 g) are obtained in quantitative yield and a transition temperature of 170° C. and a melting temperature at 230° C.

1. customThe reaction mixture is evaporated
2. customdried at high vacuum