HRID1959950

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[Si](C)(C)CCOC(=O)c1ccc2cncc(OS(=O)(=O)C(F)(F)F)c2c1

HCID58495760

未命名化合物

结构：CC(=O)N1CCC(O)(c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1

HCID66730583

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1CCC(O)(c2ccc(-c3cncc4ccc(C(=O)OCC[Si](C)(C)C)cc34)cc2)CC1

HCID66730393

未命名化合物

收率 100%

PROCEDURE

实验过程

Using 2-(trimethylsilyl)ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}isoquinoline-6-carboxylate (800 mg, 1.90 mmol) and 1-acetyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidin-4-ol (983 mg, 2.85 mmol) synthesized in Reference Example 10, the desired title compound (931 mg, yield 100%) was obtained by the same method as in Reference Example 4 (4a).

WORKUP

后处理

customsynthesized in Reference Example 10

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-18a1d1fb5eaf4159b96f4c81704379d8
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08410273B2
来源说明: uspto-grants-2013_04

反应 SMILES

FC(F)(F)S(O[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]([O:19][CH2:20][CH2:21][Si:22]([CH3:25])([CH3:24])[CH3:23])=[O:18])[CH:15]=2)[CH:10]=[N:9][CH:8]=1)(=O)=O.[C:28]([N:31]1[CH2:36][CH2:35][C:34]([C:38]2[CH:43]=[CH:42][C:41](B3OC(C)(C)C(C)(C)O3)=[CH:40][CH:39]=2)([OH:37])[CH2:33][CH2:32]1)(=[O:30])[CH3:29]>>[C:28]([N:31]1[CH2:36][CH2:35][C:34]([C:38]2[CH:43]=[CH:42][C:41]([C:7]3[C:16]4[C:11](=[CH:12][CH:13]=[C:14]([C:17]([O:19][CH2:20][CH2:21][Si:22]([CH3:25])([CH3:24])[CH3:23])=[O:18])[CH:15]=4)[CH:10]=[N:9][CH:8]=3)=[CH:40][CH:39]=2)([OH:37])[CH2:33][CH2:32]1)(=[O:30])[CH3:29]