2-(Trimethylsilyl)ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}isoquinoline-6-carboxylate → 2-(Trimethylsilyl)ethyl 4-[4-(1-acetyl-4-hydroxypiperidin-4-yl)phenyl]isoquinoline-6-carboxylate

Participants

Reaction Steps

Using 2-(trimethylsilyl)ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}isoquinoline-6-carboxylate (800 mg, 1.90 mmol) and 1-acetyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidin-4-ol (983 mg, 2.85 mmol) synthesized in Reference Example 10, the desired title compound (931 mg, yield 100%) was obtained by the same method as in Reference Example 4 (4a).

Provenance & Evidence