反应详情

Into acetone (300 ml), 4-bromo-2-fluorophenol (30 g, 157 mmol) was dissolved, to which chloromethyl methyl ether (18 ml, 237 mmol) and potassium carbonate (43 g, 235 mmol) were added, followed by stirring at room temperature for two hours. Impurities were filtered off and the filtered solution was washed with acetone. The filtrate was concentrated under reduced pressure and the residue thus obtained was purified by silica gel column chromatography (hexane:ethyl acetate, 100:0-85:15, V/V) to give the desired title compound (36.5 g, yield 82%).

1. additionwere added
2. filtrationImpurities were filtered off
3. washthe filtered solution was washed with acetone
4. concentrationThe filtrate was concentrated under reduced pressure
5. customthe residue thus obtained
6. customwas purified by silica gel column chromatography (hexane:ethyl acetate, 100:0-85:15, V/V)