4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 86661968, compound

HRID 1959964Notes

Reaction equation

HRID 1959964 reaction equation
[CH3:1][C:2]1([CH3:16])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)[O:3]1.CC1C=CC(S(O[CH2:28][P:29]([O:34][CH2:35][CH3:36])([O:31][CH2:32][CH3:33])=[O:30])(=O)=O)=CC=1>>[CH2:32]([O:31][P:29]([CH2:28][O:15][C:12]1[CH:13]=[CH:14][C:9]([B:4]2[O:3][C:2]([CH3:16])([CH3:1])[C:6]([CH3:7])([CH3:8])[O:5]2)=[CH:10][CH:11]=1)(=[O:30])[O:34][CH2:35][CH3:36])[CH3:33]

Participants

3

Reactant 2

HCID 27346244-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 4193599Diethyl P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]phosphonate

Product 1

HCID 86661968HCID 86661968, compoundYield 23%

Procedure

Using 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (313 mg, 1.42 mmol) and (diethoxyphosphoryl)methyl 4-methylbenzenesulfonate (550 mg, 1.71 mmol), the desired title compound (121 mg, yield 23%) was obtained by the same method as in Reference Example 2 (2a).

Sources & evidence

ORD record
ord-305b50eea2ec4efd9c29e474145952a7
Source dataset
uspto-grants-2013_04
Patent number
US08410273B2

Reaction notes

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