Tetrahydro-4H-pyran-4-ol → HCID 66730461, compound

HRID 1959966Notes

Reaction equation

HRID 1959966 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([OH:7])[CH2:3][CH2:2]1.Br[CH2:9][CH2:10][CH2:11][O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([O:12][CH2:11][CH2:10][CH2:9][O:7][CH:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 2776064Benzyl 3-Bromopropyl Ether

Product 1

HCID 66730461HCID 66730461, compoundYield 24%

Procedure

Using tetrahydro-4-pyranol (0.693 mL, 7.27 mmol) and [(3-bromopropoxy)methyl]benzene (1.93 mL, 10.9 mmol), the desired title compound (437 mg, yield 24%) was obtained by the same method as in Reference Example 2 (2a).

Sources & evidence

ORD record
ord-87cd57c2c33e42f599bc6fbbacf53c03
Source dataset
uspto-grants-2013_04
Patent number
US08410273B2

Reaction notes

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