Morpholine → 2-[4-(Morpholin-4-ylcarbonyl)phenoxy]ethanol

HRID 1959968Notes

Reaction equation

HRID 1959968 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[OH:7][CH2:8][CH2:9][O:10][C:11]1[CH:20]=[CH:19][C:14]([C:15](OC)=[O:16])=[CH:13][CH:12]=1>>[N:1]1([C:15]([C:14]2[CH:19]=[CH:20][C:11]([O:10][CH2:9][CH2:8][OH:7])=[CH:12][CH:13]=2)=[O:16])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 76670Benzoic acid, 4-(2-hydroxyethoxy)-, methyl ester

Product 1

HCID 667305492-[4-(Morpholin-4-ylcarbonyl)phenoxy]ethanolYield 27%

Procedure

Using morpholine (1.25 mL, 14.3 mmol) and methyl 4-(2-hydroxyethoxy)benzoate (1.00 g, 5.10 mmol), the desired title compound (345 mg, yield 27%) was obtained by the same method as in Reference Example 8.

Sources & evidence

ORD record
ord-3991bf5149c74af09cf4abe35fcafc67
Source dataset
uspto-grants-2013_04
Patent number
US08410273B2

Reaction notes

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