2-(2-Bromoethoxy)tetrahydro-2H-pyran → HCID 58495700, compound

HRID 1959972Notes

Reaction equation

HRID 1959972 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])[CH2:4][CH2:3]1.Br[CH2:19][CH2:20][O:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][O:23]1>>[O:23]1[CH2:24][CH2:25][CH2:26][CH2:27][CH:22]1[O:21][CH2:20][CH2:19][O:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyranHCID 2794620Benzyl 4-Hydroxy-1-piperidinecarboxylate

Product 1

HCID 58495700HCID 58495700, compoundYield 52%

Procedure

Using benzyl 4-hydroxy-1-piperidinecarboxylate (1.50 g, 6.35 mmol) and 2-(2-bromoethoxy)tetrahydro-2H-pyran (1.92 mL, 12.7 mmol), the desired title compound (1.2 g, yield 52%) was obtained by the same method as in Reference Example 2 (2a).

Sources & evidence

ORD record
ord-067950747b864f9fa9c1211fabb5932f
Source dataset
uspto-grants-2013_04
Patent number
US08410273B2

Reaction notes

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