Methanesulfonyl chloride → HCID 66730432, compound

HRID 1959973Notes

Reaction equation

HRID 1959973 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][O:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>>[CH3:17][S:18]([N:14]1[CH2:13][CH2:12][CH:11]([O:10][CH2:9][CH2:8][O:7][CH:2]2[CH2:3][CH2:4][CH2:5][CH2:6][O:1]2)[CH2:16][CH2:15]1)(=[O:20])=[O:19]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 66730412HCID 66730412, compound2×

Product 1

HCID 66730432HCID 66730432, compoundYield 83%

Procedure

Using 4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]piperidine (561 mg, 2.54 mmol) synthesized in (17b) and methanesulfonyl chloride (375 μL, 3.06 mmol), the desired title compound (618 mg, yield 83%) was obtained by the same method as in Reference Example 2 (2c).

Sources & evidence

ORD record
ord-b2ad346d830543daa717365df00236f4
Source dataset
uspto-grants-2013_04
Patent number
US08410273B2

Reaction notes

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