Tetrahydrofuran → 4-Chloro-5-fluoro-1H-pyrrolo(2,3-b)pyridine

HRID 195998Notes

Reaction equation

HRID 195998 reaction equation
[CH2:23]([N+:24]([CH2:25][CH2:26][CH2:27][CH3:28])([CH2:29][CH2:30][CH2:31][CH3:32])[CH2:33][CH2:34][CH2:35][CH3:36])[CH2:37][CH2:38][CH3:39].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][c:7]1[F:8])[n:9]([Si:12]([CH:13]([CH3:14])[CH3:15])([CH:16]([CH3:17])[CH3:18])[CH:19]([CH3:20])[CH3:21])[cH:10][cH:11]2.[F-:22].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][c:7]1[F:8])[nH:9][cH:10][cH:11]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 534382514-Chloro-5-fluoro-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 497616114-Chloro-5-fluoro-1H-pyrrolo(2,3-b)pyridine

Sources & evidence

ORD record
ord-8cd3de6b697e4642bc78d41ee26139bb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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