HRID19600

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NCc1ccc(C(=O)Nc2ccc(N)cc2)cc1

HCID67319189

未命名化合物

结构：CS(=O)(=O)c1nc(-c2ccc(-c3ccccc3)cc2)cc2ccnn12

HCID67319401

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NCc1ccc(C(=O)Nc2ccc(Nc3nc(-c4ccc(-c5ccccc5)cc4)cc4ccnn34)cc2)cc1

HCID67319580

未命名化合物

CONDITIONS

反应条件

温度: 130 °C

PROCEDURE

实验过程

Under an inert gas atmosphere at 130° C. bath temperature is heated neat a mixture of 5-biphenyl-4-yl-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine (compound B1) and [4-(4-amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester (compound G1) overnight. The crude product is purified by silica gel flash chromatography.

WORKUP

后处理

customThe crude product is purified by silica gel flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7bb89b1754674576bfaa0c2cfa3b5187
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745446B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11](S(C)(=O)=O)[N:10]3[N:17]=[CH:18][CH:19]=[C:9]3[CH:8]=2)=[CH:3][CH:2]=1.[C:26]([O:30][C:31](=[O:50])[NH:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37]([C:40](=[O:49])[NH:41][C:42]2[CH:47]=[CH:46][C:45]([NH2:48])=[CH:44][CH:43]=2)=[CH:36][CH:35]=1)([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:31](=[O:50])[NH:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37]([C:40](=[O:49])[NH:41][C:42]2[CH:43]=[CH:44][C:45]([NH:48][C:11]3[N:10]4[N:17]=[CH:18][CH:19]=[C:9]4[CH:8]=[C:7]([C:4]4[CH:5]=[CH:6][C:1]([C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=5)=[CH:2][CH:3]=4)[N:12]=3)=[CH:46][CH:47]=2)=[CH:36][CH:35]=1)([CH3:29])([CH3:27])[CH3:28]