HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 19600Generated: October 26, 2026
[4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester → {4-[4-(5-Biphenyl-4-yl-pyrazolo[1,5-c]pyrimidin-7-ylamino)-phenylcarbamoyl]benzyl}-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/19600
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | [4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester | HCID 67319189 | — |
| Reactant | 5-Biphenyl-4-yl-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine | HCID 67319401 | — |
| Product | {4-[4-(5-Biphenyl-4-yl-pyrazolo[1,5-c]pyrimidin-7-ylamino)-phenylcarbamoyl]benzyl}-carbamic acid tert-butyl ester | HCID 67319580 | — |
Reaction Steps
Under an inert gas atmosphere at 130° C. bath temperature is heated neat a mixture of 5-biphenyl-4-yl-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine (compound B1) and [4-(4-amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester (compound G1) overnight. The crude product is purified by silica gel flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07745446B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-7bb89b1754674576bfaa0c2cfa3b5187 |
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| Source note | uspto-grants-2010_06 |
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