HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Saxagliptin hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Saxagliptin Hydrate | HCID 53297473 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | Saxagliptin hydrochloride | HCID 49800073 | — |
Reaction Steps
Saxagliptin monohydrate, form H-1 (1 g) was suspended in 10 ml of 1-butanol and 0.275 ml of conc. HCl was added. A thick suspension was obtained. An additional 15 ml of 1-butanol were added and the suspension stirred at RT for an additional 30 min. The suspension was then filtered, yielding 640 mg of Saxagliptin HCl, form D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410288B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-aa0748df391245c2a215b420954f909d |
| Source note | uspto-grants-2013_04 |