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HRID1960060

反应详情

EQUATION

反应方程式

HRID 1960060 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2.O
HCID53297473

未命名化合物

PRODUCTS

生成物

1
结构：Cl.N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2
HCID49800073

Saxagliptin hydrochloride

C18H26ClN3O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCO
溶剂HCID263

1-Butanol

C4H10O

2 次

PROCEDURE

实验过程

Saxagliptin monohydrate, form H-1 (1 g) was suspended in 10 ml of 1-butanol and 0.275 ml of conc. HCl was added. A thick suspension was obtained. An additional 15 ml of 1-butanol were added and the suspension stirred at RT for an additional 30 min. The suspension was then filtered, yielding 640 mg of Saxagliptin HCl, form D.

WORKUP

后处理

  1. customA thick suspension was obtained
  2. filtrationThe suspension was then filtered