HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1960131Generated: October 30, 2026
Ethanol → 6-Fluoro-[1,1';4'1'']terphenyl-3,4-diamine
https://huagongshe.com/reaction/1960131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-Fluoro-5-nitro-[1,1';4'1'']terphenyl-4-ylamine | HCID 67446509 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-Fluoro-[1,1';4'1'']terphenyl-3,4-diamine | HCID 67445664 | — |
Reaction Steps
To a solution of EtOH (40 mL), H2O (10 mL) and compound 13-2 (663 mg, 2.1 mmol) was added iron (889 mg, 16 mmol) and NH4Cl (562 mg, 10.5 mmol). The resulting suspension was allowed to stir for 18 h at 50° C. The crude suspension was diluted with copious amounts of EtOAc and filtered over a pad of Celite™. The resulting yellow solution was concentrated in vacuo then purified on ISCO (EtOAc/Hexanes=7/3) to give title compound 13-3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08410284B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-d760e5fbe1bd4f1d80b10a0875f5bbf7 |
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| Source note | uspto-grants-2013_04 |
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