反应详情

温度

50 °C

To a solution of EtOH (40 mL), H2O (10 mL) and compound 13-2 (663 mg, 2.1 mmol) was added iron (889 mg, 16 mmol) and NH4Cl (562 mg, 10.5 mmol). The resulting suspension was allowed to stir for 18 h at 50° C. The crude suspension was diluted with copious amounts of EtOAc and filtered over a pad of Celite™. The resulting yellow solution was concentrated in vacuo then purified on ISCO (EtOAc/Hexanes=7/3) to give title compound 13-3.

1. filtrationfiltered over a pad of Celite™
2. concentrationThe resulting yellow solution was concentrated in vacuo
3. customthen purified on ISCO (EtOAc/Hexanes=7/3)