HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1960132Generated: October 30, 2026
Ethanol → 5-Biphenyl-4-yl-6-fluoro-1,3-dihydro-benzoimidazole-2-thione
https://huagongshe.com/reaction/1960132
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 6-Fluoro-[1,1';4'1'']terphenyl-3,4-diamine | HCID 67445664 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Biphenyl-4-yl-6-fluoro-1,3-dihydro-benzoimidazole-2-thione | HCID 86640507 | — |
Reaction Steps
To a solution of EtOH (20 mL), H2O (4 mL) and KOH (593 mg, 11 mmol) was added compound 13-3 (2.46 g, 8.8 mmol). CS2 (0.65 mL, 11 mmol) was then added and the suspension was heated to reflux for 2 h. The reaction mixture was cooled to 25° C., then 40 mL of H2O and 0.8 mL of acetic acid were added resulting in a tan precipitate. The precipitate was collected by vacuum filtration resulting in title compound 13-4, which required no further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08410284B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-3dba3664ddc948c79fe92be5c813e4bc |
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| Source note | uspto-grants-2013_04 |
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