HRID19602

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NCc1ccc(C(=O)Nc2ccc(Nc3nc(-c4ccc5cc(OCc6ccccc6)ccc5c4)cc4ccnn34)cc2)cc1

HCID67319336

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NCc1ccc(C(=O)Nc2ccc(Nc3nc(-c4ccc5cc(O)ccc5c4)cc4ccnn34)cc2)cc1

HCID136388310

未命名化合物

收率 48%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A mixture of (4-{4-[5-(6-benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester (compound A2)(750 mg) and Pd/C (10%, 100 mg) in dioxane (100 ml) is hydrogenated (1.1 bar) at 80° C. for 3 days. The reaction mixture is filtered and the filtrate is evaporated. After silica gel flash chromatography the product is obtained as colorless solid in 48% yield.

WORKUP

后处理

customat 80° C.
customfor 3 days
filtrationThe reaction mixture is filtered
customthe filtrate is evaporated
customAfter silica gel flash chromatography the product is obtained as colorless solid in 48% yield

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-974a081e77a3417da4398a24d196880c
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745446B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([O:5][C:6](=[O:52])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:51])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]3[N:29]4[N:30]=[CH:31][CH:32]=[C:28]4[CH:27]=[C:26]([C:33]4[CH:42]=[CH:41][C:40]5[C:35](=[CH:36][CH:37]=[C:38]([O:43]CC6C=CC=CC=6)[CH:39]=5)[CH:34]=4)[N:25]=3)=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>O1CCOCC1.[Pd]>[C:1]([O:5][C:6](=[O:52])[NH:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:15](=[O:51])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]3[N:29]4[N:30]=[CH:31][CH:32]=[C:28]4[CH:27]=[C:26]([C:33]4[CH:42]=[CH:41][C:40]5[C:35](=[CH:36][CH:37]=[C:38]([OH:43])[CH:39]=5)[CH:34]=4)[N:25]=3)=[CH:19][CH:18]=2)=[CH:13][CH:14]=1)([CH3:4])([CH3:2])[CH3:3]