反应详情

To a solution of N-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (1.30 g) in a mixed solvent of toluene (60 ml) and tetrahydrofuran (30 ml) was added Lawesson's reagent (1.94 g), and the mixture was heated under reflux for 3 hr. The reaction solution was concentrated under reduced pressure, and the residue was purified by basic silica gel column chromatography (ethyl acetate:hexane=5:95-40:60), and recrystallized from ethyl acetate-hexane to give the title compound (0.063 g, yield 5%) as colorless crystals.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hr
3. concentrationThe reaction solution was concentrated under reduced pressure
4. customthe residue was purified by basic silica gel column chromatography (ethyl acetate:hexane=5:95-40:60)
5. customrecrystallized from ethyl acetate-hexane