Diethylenetriaminepentaacetic acid → DTPA dianhydride

HRID 1960969Notes

Reaction equation

HRID 1960969 reaction equation
[CH2:1]([N:12]([CH2:24][C:25]([OH:27])=[O:26])[CH2:13][CH2:14][N:15]([CH2:20][C:21]([OH:23])=O)[CH2:16][C:17]([OH:19])=[O:18])[CH2:2][N:3]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][C:5]([OH:7])=O.C(OC(=O)C)(=O)C>N1C=CC=CC=1>[CH2:20]1[N:15]([CH2:14][CH2:13][N:12]([CH2:24][C:25]([OH:27])=[O:26])[CH2:1][CH2:2][N:3]2[CH2:8][C:9](=[O:10])[O:11][C:5](=[O:7])[CH2:4]2)[CH2:16][C:17](=[O:19])[O:18][C:21]1=[O:23]

Participants

4

Reactant 2

HCID 3053Diethylenetriaminepentaacetic acidHCID 7918Acetic Anhydride

Product 1

HCID 100825DTPA dianhydride

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.08 gram of DTPA (2.7 mmol), 2 mL acetic anhydride and 1.3 mL pyridine were stirred for 48 hours at 60° C. and then the reaction mixture was filtered at room temperature. The solid product washed to be free of pyridine with acetic anhydride and then with diethyl ether, and is dried.

Workup

  1. filtrationthe reaction mixture was filtered at room temperature
  2. washThe solid product washed
  3. dry with materialwith diethyl ether, and is dried

Sources & evidence

ORD record
ord-ab2075a5fe9546ce978092d263c60940
Source dataset
uspto-grants-2013_04
Patent number
US08412306B2

Reaction notes

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