Thiosemicarbazide → HCID 178527901, compound

HRID 19613Notes

Reaction equation

HRID 19613 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[CH:11]=[CH:12]OC)=[CH:4][CH:3]=1.[NH2:17][NH:18][C:19]([NH2:21])=[S:20]>CO>[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:21][C:19](=[S:20])[N:18]3[N:17]=[CH:12][CH:11]=[C:10]3[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2723789ThiosemicarbazideHCID 673183211-(4-Iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione2×

Product 1

HCID 178527901HCID 178527901, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione (compound F1)(1.9 g) and thiosemicarbazide (5 g) in methanol (220 ml) is heated to reflux temperature. After the reaction is completed the solid is filtered and washed with methanol. The filtrate with the product is purified by flash silica gel chromatography.

Workup

  1. temperatureis heated
  2. temperatureto reflux temperature
  3. filtrationis filtered
  4. washwashed with methanol
  5. customThe filtrate with the product is purified by flash silica gel chromatography

Sources & evidence

ORD record
ord-1a283ebeecc94dc18563be03e16f73f1
Source dataset
uspto-grants-2010_06
Patent number
US07745446B2

Reaction notes

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