HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 59436393, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 59436342 | HCID 59436342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59436393 | HCID 59436393 | — |
Reaction Steps
To a solution of (2S,4S)-tert-butyl 4-hydroxy-2-methyl-2-(thiazol-2-ylcarbamoyl)pyrrolidine-1-carboxylate (0.49 g, 1.5 mmol) in CH2Cl2 was added TFA (1 ml, excess). The reaction mixture was stirred at RT for 14 h and concentrated. The residue was used for the next step without purification. LC/MS [M+H]+: 228; Ret time (Method F): 0.46 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415340B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ded2813ce1f64aa29808ad4871cd79c2 |
| Source note | uspto-grants-2013_04 |