Trifluoroacetic acid → HCID 59436448, compound

HRID 1961412Notes

Reaction equation

HRID 1961412 reaction equation
[F:1][C:2]1([F:23])[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14](=[O:22])[NH:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:3]1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:23][C:2]1([F:1])[CH2:6][NH:5][C@H:4]([C:14]([NH:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)=[O:22])[CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59436366HCID 59436366, compound

Product 1

HCID 59436448HCID 59436448, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of (S)-tert-butyl 4,4-difluoro-2-(pyrazin-2-ylcarbamoyl)pyrrolidine-1-carboxylate 116B (1.6 g, 4.87 mmol) in CH2Cl2(30 mL) was added trifluoroacetic acid (7.24 mL, 97 mmol). The mixture was stirred for 4 hrs, the solvent was evaporated to dryness and the residue 116C was used in the next reaction without further purification. LC/MS [M+H]+: 229; Ret time (Method F): 0.61 min.

Workup

  1. customthe solvent was evaporated to dryness
  2. customthe residue 116C was used in the next reaction without further purification
  3. custom0.61 min.

Sources & evidence

ORD record
ord-21e951c7725445469af646665a9a36b4
Source dataset
uspto-grants-2013_04
Patent number
US08415340B2

Reaction notes

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