(1S,3S,5S)-tert-Butyl 3-(pyrazin-2-ylcarbamoyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate → (1S,3S,5S)-N-(Pyrazin-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide

HRID 1961414Notes

Reaction equation

HRID 1961414 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[NH:7][C:8]([C@@H:10]1[CH2:15][C@H:14]2[C@H:12]([CH2:13]2)[N:11]1C(OC(C)(C)C)=O)=[O:9].ClC1N=C(NC2NN=C(C3CC3)C=2)N=C(N2C[C@H](F)C[C@H]2C(NC2C=NC=CN=2)=O)N=1>>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[NH:7][C:8]([C@@H:10]1[CH2:15][C@H:14]2[C@H:12]([CH2:13]2)[NH:11]1)=[O:9]

Participants

3

Reactant 2

HCID 59436392(1S,3S,5S)-tert-Butyl 3-(pyrazin-2-ylcarbamoyl)-2-azabicyclo[3.1.0]hexane-2-carboxylateHCID 178522397HCID 178522397, compound

Product 1

HCID 59436362(1S,3S,5S)-N-(Pyrazin-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide

Procedure

Compound 121C was prepared starting from 121B using the procedure as described in 65C. LC/MS [M+H]+: 205; Ret time (Method C): 0.70 min.

Workup

  1. custom0.70 min.

Sources & evidence

ORD record
ord-7aa7cdffd4a64620b2729d72dafd3fcd
Source dataset
uspto-grants-2013_04
Patent number
US08415340B2

Reaction notes

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