Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1961427생성일: 2026년 10월 25일
4-Fluoro-3-(trifluoromethyl)benzonitrile → 4-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile
https://huagongshe.com/reaction/1961427
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Fluoro-3-(trifluoromethyl)benzonitrile | HCID 144255 | — |
| 반응물 | Sodium methanesulfinate | HCID 2733271 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile | HCID 45933716 | — |
반응 단계
4-Fluoro-3-(trifluoromethyl)benzonitrile (400 mg, 2.12 mmol) was suspended together with sodium methanesulfinate (216 mg, 2.12 mmol) in DMSO (2 ml) and stirred at 80° C. for 22 hours. The reaction was then cooled, diluted with 25 ml H2O and filtered. Filtered solids were evaporated from toluene to give 536 mg of the title substance (quant).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08415333B2 |
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| 출처 데이터셋 | uspto-grants-2013_04 |
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| ORD ID | ord-25131b47e8044a0abb5bb5e600f8a7d5 |
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| 출처 메모 | uspto-grants-2013_04 |
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